Toxicology : principles and applications / [edited by] Raymond J.M. Niesink, John De Vries, Mannfred A. Hollinger.

Includes bibliographical references and index.

Fundamental Principles: 1.Toxicology: history and scope of the field - J.H. Koeman -- 2.Exposure: qualitative and quantitative aspects - A. Musch -- 3.Biotransformation: detoxication and bioactivation - B.J Blaauboer - 4.Biotransformation: species differences and determining factors - A. Bast -- 5.Absorption, distribution and elimination of xenobiotics - R.J.M. Niesink -- 6.Toxicokinetics: quantitative aspects - J. de Vries -- 7.Dose-time-effect relationships - A. Musch. Molecular Aspects of Toxicity: 8.Structure-activity relationships - J.L.M. Hermens -- 9.Toxicity of mixtures - A. Musch -- 10.Cytotoxicity: molecular mechanisms of cell death - J. do Vries --11.Genetic toxicology - Ph. Vanparys, Th.M.C.M. deKuk and F.-J. van Schooten -- 12.Introduction to carcinogenesis - H. Van Cauteren, Th.M. deKuk and F.-J. van Schooten -- 13.Cancer risk evaluation - H. Van Cauteren, Th.M. deKuk and F.-J. van Schooten. Organ Toxicology: 14.Hazard identification, risk assessment, regulation and legislation - K.N. Woodward -- 15.Cytopathology: general response patterns and morphological aspects - A Penninks -- 16.Necrosis and apoptosis irreversibility of cell damage and cell death - A. Verheyen. Organs Involved in Absorption and Elimination: 17.Dermatotoxicology: toxicological pathologly and methodological aspects - R.J.M. Niesink -- 18.Respiratory toxicology: pathophysiology, toxicological pathology and mechanisms of toxicity - V.J. Feron, R.B. Beems, P.G.J. Reuzel and A. Zwart -- 19.Inhalatory exposure and metholodogical aspects - V.J. Feron, R.B. Beems, P.G.J. Reuzel and A. Zwart -- 20.Gastrointestinal toxicology: structure, function and enterohepatic circulation - W. Coussement -- 21.Gastrointestinal toxicology: toxicological pathology and sources of intestinal toxicity - W. Coussement -- 22.Hepatotoxicology: structure, function and toxicological pathology - J.Vandernberghe -- 23..Hepatotoxicology: mechanisms of liver toxicity and methodological aspects - J. Vandernberghe -- 24.Nephrotoxicology: toxicological pathology and biochemical toxicology - J.F. Nagelkerke -- 25.Organ perfusion techniques: invitro toxicity testing - A.Sj. Koster. Organs Involved in Maintaining Homeostasis: 26.Cardiovascular toxicology: toxicological pathology and methodological aspects - A. Verheyen -- 27.Toxicology of the blood: pathophysiology, toxicological pathology and mechanistic aspects - J.J.M. Marx -- 28.Immunotoxicologly: determination of immunotoxic effects and immunotoxicity mechanisms - J.G. Vos and H. van Loveren -- 29.Immunotoxicology: examples of immunotoxic substances - J.G. Vos and H. van Loveren -- 30.Endocrinotoxicology: methodological aspects - F.X.R. van Leeuwen, M.A.M. Krajnc-Frenken, and J.G. Loeber -- 31.General reproductive toxicology - P.W.J. Peters and J.M. Garbis-Berkvens -- 32.Special reproductive toxicology - P.W.J. Peters and J.M. Garbis-Berkvens -- 33.Anatomy and toxicological pathology of the nervous system - A. Bast -- 34.Functional neurotoxicology - T.A. de Vlieger -- 35.Neurobehavioral toxicology - R.J.M. Niesink. Application Areas: 36.Introduction to nutritional toxicology - J.H.Koeman -- 37.Food toxicity: the toxicological history of aspartame - J.C.S. Kleinjans -- 38.Medical and clinical toxicologly - B.Sangster -- 39.Ecotoxicology - N.M. van Straalen -- 40.Occupational toxicology - P.J.A. Borm and P.Th. Henderson.

Aimed at the undergraduate, this text is also intended to meet the needs of all levels of toxicology students. The emphasis is on an analytical approach to problems, with coverage of topics such as molecular aspects of toxicity, organ toxicity and organs involved in maintaining homeostasis.