Combinatorial chemistry and molecular diversity in drug discovery / edited by Eric M. Gordon and James F. Kerwin.

Includes bibliographical references and index.

Part I.Combinatorial chemistry and molecular diversity: an introduction -- 1.Historical overview of the developing field of molecular diversity. John C. Chabala ... -- 2.Strategies in the design and synthesis of chemical libraries. Eric M. Gordon. -- 3.Solid-phase peptide synthesis, lead generation, and optimization. Bruce Seligman, Michael Lebl, Kit S. Lam -- 4.Light-directed chemical synthesis of positionally encoded peptide arays. Jeffrey W. Jacobs ... [et al] -- 5.Conformationally restriced peptide and peptidomimetic libraries. Alex A. Virgilio and Jonathan A. Ellman -- 6.Submonomer approaches for the generation of molecular diversity: nonatural oligomer and organic template libraries. Lutz S. Richeter ... [et al] -- Part II.Small molecule libraries: overview of issues and strategies in librar design. John J. Baldwin -- 9.Protease inhibitor libraries. Dinesh V. Patel and David A. Campbell -- 10.Heterocyclic combinatorial chemistry: Azine and Diazepine pharmacophores. Michkail F. Gordeev and Dinesh V. Patel ... -- 11.Scaffolds for small molecule libraries -- 12.Application of combinatorial chemistry to biopolymers. Edmund J. Moran ... 13.Oligosaccharide and glycoconjugate solid-phase synthesis technologies for drug disocvery. Michael J. Sofia ... -- 14.Encoded combinatorial chemistry. Jeffrey W. Jacobs and Zhi-Jie Ni -- 15.Parallel organic synthesis in array format. Steven E. Hall -- 16.Synthetic organic chemsitry on solid support. Stephen W. Kaldor and Miles G. Siegel -- Part III.Automation, analytical, and computational methods -- 17.Automation of combinatorial chemistry for large libraries -- 18.Analytical chemistry issues in combinatorial organic synthesis. William L. Fitch, Gary C. Look, and George Detre -- 19.Quantifying diversity. Yvonne C. Martin, Robert D. Brown, and Mark G. Bures -- Part IV.Biological diversity -- 20.Protein scaffolds for peptide libraries. Ronald H. Hoess -- 21.Combinatorial biosynthesis of "unnatrual" natural products. Chaitan Khosla -- Part V.Screening -- 22.Strategies for screening large combinatorial libraries. Nolan H. Sigal and Daniel Chelsky -- Part VI.Combinatorial drug screening and development -- 24.Combinatorial drug screening and development. Judd Berman and Russell J. Howard -- 25.ADME/PK assays in screening for orally active drug candidates. Jacqueline Gibbons, Eric W. Taylor and Rene A. Braeckman -- 26.Combinatorial technologies: prospects and future issues. James F. Kerwin, Jr. -- 27.Appendix: Combinatorial chemistry information management. David Weininger ..

This book applies combinatorial technologies to drug discovery and development and highlights the critical concept and issues that are entailed in implementation.