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The handbook of medicinal chemistry : principles and practice / edited by Andrew M. Davis and Simon Ward.

By: Contributor(s): Material type: TextTextSeries: RSC smart materialsPublication details: Cambridge : Royal Society of Chemistry, 2014.Description: 700 pages ; 24 cmISBN:
  • 9781849736251 (hbk.) :
  • 9781849736251
Subject(s): DDC classification:
  • 615.19 DAV
LOC classification:
  • RS403
Contents:
1.Physicochemical properties and compound quality. M. Paul Gleeson, Paul D. Leeson and Hnas van der Waterbeemd -- 2.Parallel syntehsis and library design. Andy Merritt -- 3.Useful computational chemistry tools for medicinal chemistry -- 4.Structure-based design for medicinal chemists. Jeff Blaney and Andrew M. Davis -- 5.Fragement based lead discovery. Roderick E. Hubbard -- 6.Quantitative structure-activity relationships. Andrew M. Davis -- 7.Drug metabolism. C. W. Vose and R. M. J. Ings -- 8.Prediction of human pharmacokinetics, exposure and therapeutic dose in drug discovery. Dermot F. McGinnity, Ken Grime and Peterj. H,. Webbor -- 9.Molecular biology for medicinal chemists. Giselle R. Wiggins, Jayesh C. Patel, Fional H. Marshall and Ali Jazayeri -- 10,Assays. Tim Hammonds and Peter B. Simpson -- 11.In viro biology: measuring pharacological activity Iain G. Dougall -- 12.Animal models: practical use and considerations. Milenko Cicmil and Robbie L. McLeod -- 13.Bioinformatics for medicinal chemistry. Niklas Blomberg, Bryn Williams-Jones -- 14.Translational science -- 15.Discovery toxicology in lead optimisation -- 16.Toxicology and drug development. Mark W. Powley -- 17.Patents for medicines. Paul A. Brady and Gordon Wright -- 18.The modern drug discovery process. Mark C. Noe -- 19.Target validation for medicinal chemists -- 20.Lead generation -- 21.Lead optimisation: what you should know! -- 22.Pharmaceutical properties - the importance of solid form selection. Robert Docherty and Nicola Clear -- 23.The chemical development and medicinal chemistry interface. David Lathbury and David Ennis -- 24.Project management -- 25.Clinical drug development. Maarten Kraan -- 26.Aleglitazar: a case study -- 27.Lessons learned from the discovery and development of Lapatinib/Tykerb. G. Stuart Cockerill and Karen E. Lackey -- 28.Daring to be different: The discovery of Ticagrelor. Bob Humphries and John Dixon.
Summary: Drug discovery is a constantly developing and expanding area of research. Developed to provide a comprehensive guide, this handbook covers the past, present and future of the entire drug development process. Highlighting the recent successes and failures, this book will help readers to understand the factors governing modern drug discovery from the initial concepts through to translational science and intellectual property.
Holdings
Item type Current library Call number Copy number Status Date due Barcode
Long Loan TUS: Midlands, Main Library Athlone General Lending 615.19 DAV (Browse shelf(Opens below)) 1 Available 223321

Title from content provider.

Includes bibliographical references.

1.Physicochemical properties and compound quality. M. Paul Gleeson, Paul D. Leeson and Hnas van der Waterbeemd -- 2.Parallel syntehsis and library design. Andy Merritt -- 3.Useful computational chemistry tools for medicinal chemistry -- 4.Structure-based design for medicinal chemists. Jeff Blaney and Andrew M. Davis -- 5.Fragement based lead discovery. Roderick E. Hubbard -- 6.Quantitative structure-activity relationships. Andrew M. Davis -- 7.Drug metabolism. C. W. Vose and R. M. J. Ings -- 8.Prediction of human pharmacokinetics, exposure and therapeutic dose in drug discovery. Dermot F. McGinnity, Ken Grime and Peterj. H,. Webbor -- 9.Molecular biology for medicinal chemists. Giselle R. Wiggins, Jayesh C. Patel, Fional H. Marshall and Ali Jazayeri -- 10,Assays. Tim Hammonds and Peter B. Simpson -- 11.In viro biology: measuring pharacological activity Iain G. Dougall -- 12.Animal models: practical use and considerations. Milenko Cicmil and Robbie L. McLeod -- 13.Bioinformatics for medicinal chemistry. Niklas Blomberg, Bryn Williams-Jones -- 14.Translational science -- 15.Discovery toxicology in lead optimisation -- 16.Toxicology and drug development. Mark W. Powley -- 17.Patents for medicines. Paul A. Brady and Gordon Wright -- 18.The modern drug discovery process. Mark C. Noe -- 19.Target validation for medicinal chemists -- 20.Lead generation -- 21.Lead optimisation: what you should know! -- 22.Pharmaceutical properties - the importance of solid form selection. Robert Docherty and Nicola Clear -- 23.The chemical development and medicinal chemistry interface. David Lathbury and David Ennis -- 24.Project management -- 25.Clinical drug development. Maarten Kraan -- 26.Aleglitazar: a case study -- 27.Lessons learned from the discovery and development of Lapatinib/Tykerb. G. Stuart Cockerill and Karen E. Lackey -- 28.Daring to be different: The discovery of Ticagrelor. Bob Humphries and John Dixon.

Drug discovery is a constantly developing and expanding area of research. Developed to provide a comprehensive guide, this handbook covers the past, present and future of the entire drug development process. Highlighting the recent successes and failures, this book will help readers to understand the factors governing modern drug discovery from the initial concepts through to translational science and intellectual property.

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