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Lipophilicity in drug action and toxicology / edited by Vladimir Pliška, Bernard Testa, Han van de Waterbeemd.

Contributor(s): Material type: TextTextSeries: Methods and principles in medicinal chemistry ; v. 4 | Methods and principles in medicinal chemistry ; v. 4Publication details: Weinheim ; Cambridge : VCH, c1996.Description: xxv, 438p. : ill. ; 25cmISBN:
  • 9783527293834 :
  • 9783527293834
Subject(s): DDC classification:
  • 615.19 PLI
Contents:
1.Lipophilicty: the empirical tool and the fundamental objective. An introduction -- 2.Lipophilicity: a history -- 3.Thermodynamicsof van der Waals and hydrophobic interactions -- 4.Intramolecular interactions encoded in lipophilicity: their nature and significance -- 5.Lipophilicty measurement by reversed-pahse high performance liquid chromatography (RP-HPLC) -- 6.Centrifugal partition chromatography for lipophilicity measurements -- 7.Assessment of distribution-pH profiles -- 8.Estimation of lipophilicyt by reversed-phase thin-layer chromatography -- 9.The future of log P calculation -- 10.Theoretical calculation of partition coefficients -- 11.Cellular automata model of partitioning between liquid phases --- 12.The molecular lipophilicity potential (MLP): a new tool for log P calculations and docking and in comparative molecular field analysis (CoFMA) -- 13.Hydrophobic fields in quantitative structure activity relationships -- 14.Physico-chemical and biological factors that influence a drug's ecllular permeability by passive diffusion -- 15.Lipophilicity of metabolites and its role in biotransformaton -- 16.The role of lipophilicty in biological response to drugs and endogenous ligands -- 17.Membrane transport and cellular distribution -- 18.Applications of a solvation equation to drug transport -- 19.Enviromental hazard assessment using lipophilicty data -- 20.Lipophilicity in peptide chemistry and peptide drug design -- 21.Side chain lipophilicity of noncoded amino acids: values -- 22.The application of the intermolecular force model to bioactivity, peptide and protein quantitative structure-activity relationships -- 23.Lipophilicty descriptors for structure-properity correlation studies: overview of experimental and theoretical methods and a benchmark of log P calculations.
Summary: This work features coverage of lipophilicity in drug action and toxicology.
Holdings
Item type Current library Call number Copy number Status Date due Barcode
Long Loan TUS: Midlands, Main Library Athlone General Lending 615.19 PLI (Browse shelf(Opens below)) 1 Available 107263

Includes index.

Includes bibliographical references and index.

1.Lipophilicty: the empirical tool and the fundamental objective. An introduction -- 2.Lipophilicity: a history -- 3.Thermodynamicsof van der Waals and hydrophobic interactions -- 4.Intramolecular interactions encoded in lipophilicity: their nature and significance -- 5.Lipophilicty measurement by reversed-pahse high performance liquid chromatography (RP-HPLC) -- 6.Centrifugal partition chromatography for lipophilicity measurements -- 7.Assessment of distribution-pH profiles -- 8.Estimation of lipophilicyt by reversed-phase thin-layer chromatography -- 9.The future of log P calculation -- 10.Theoretical calculation of partition coefficients -- 11.Cellular automata model of partitioning between liquid phases --- 12.The molecular lipophilicity potential (MLP): a new tool for log P calculations and docking and in comparative molecular field analysis (CoFMA) -- 13.Hydrophobic fields in quantitative structure activity relationships -- 14.Physico-chemical and biological factors that influence a drug's ecllular permeability by passive diffusion -- 15.Lipophilicity of metabolites and its role in biotransformaton -- 16.The role of lipophilicty in biological response to drugs and endogenous ligands -- 17.Membrane transport and cellular distribution -- 18.Applications of a solvation equation to drug transport -- 19.Enviromental hazard assessment using lipophilicty data -- 20.Lipophilicity in peptide chemistry and peptide drug design -- 21.Side chain lipophilicity of noncoded amino acids: values -- 22.The application of the intermolecular force model to bioactivity, peptide and protein quantitative structure-activity relationships -- 23.Lipophilicty descriptors for structure-properity correlation studies: overview of experimental and theoretical methods and a benchmark of log P calculations.

This work features coverage of lipophilicity in drug action and toxicology.

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