Mechanistic toxicology : the molecular basis of how chemicals disrupt biological targets / Urs A. Boelsterli.

Previous ed.: New York: Taylor & Francis, 2003.

Includes bibliographical references and index.

Types of toxic responses -- Organ-selective toxicity -- Cellular transport and selective accumulation of potentially toxic xenobiotics -- Bioactivation of xenobiotics to reactive metabolites -- Xenobiotic-induced oxidative stress: cell injury, signaling, and gene regulation -- Disruption of cellular calcium homeostasis -- Mechanisms of necrotic and apoptotic cell death -- Impairment of cell proliferation and tissue repair -- Covalent binding of reactive metabolites to cellular macromolecules -- Immune mechanisms -- Cytokine-mediated toxicity -- Specific inactivation of enzymes and other proteins -- Interactions of xenobiotics with ion transporters -- Nuclear receptor-mediated toxicity -- Activation or disruption of cellular signal transduction by xenobiotics -- Disruption of mitochondrial function and mitochondria-mediated toxicity -- Novel mechanisms derived from systems toxicology.

The author provides an introduction to an important, but often neglected, area within the toxicological sciences. The text gives new insights into the processes and mechanisms underlying the toxicity of chemicals and explains how foreign compounds exert their potentially damaging effects on cells and tissues.