TY  - BOOK
AU  - Taylor,J.B.
AU  - Kennewell,P.D.
AU  - Kennewell,P.D.
TI  - Modern medicinal chemistry
T2  - Ellis Horwood series in pharmaceutical technology
SN  - 9780135903995 (pbk) :
U1  - 615.1 TAY 
PY  - 1993///
CY  - New York, London
PB  - Ellis Horwood
KW  - Pharmaceutical chemistry
KW  - Biotechnology
KW  - thema
KW  - Chemistry
KW  - Pharmacology
KW  - Chemistry, Pharmaceutical
KW  - Pharmacokinetics
KW  - Drugs
N1  - Includes bibliographical references (p. [281]-285) and index; Definitions -- Drug development -- Scene today -- Major processes of drug action -- Pharmaceutical phase -- Introduction to biopharmaceutics -- Physicochemical principles -- Formulation science -- Routes of administration of medicines -- Controlled release dosage forms -- Pharmacokinetic phase -- Absorption processes -- Distribution -- Clearance -- Sites of drug metabolism -- Biotransformation -- Metabolic pathways -- Pharmacodynamic phase -- Cell structures -- Cell membrane -- Receptor theories -- Types of binding in drug-receptor interactions -- Use of radio-labelled ligands -- Isolation of receptors -- Primary and secondary messengers -- Intracellular proteinaceous receptors -- DNA as a receptor -- Enzymes -- Drug discovery processes -- Sources of lead structures -- Macromolecular targets for drug design -- Computational chemistry -- Computer graphics -- Modelling drug-receptor interactions -- Drug design methods -- Applications of drug design techniques -- Optimisation of lead structures
N2  - An introduction to medicinal chemistry including computing and other modern techniques. The main objective of medicinal chemistry is the design and synthesis of new medicines, and this book covers widely this rapidly developing and important field of chemistry
ER  -