TY - BOOK AU - Gad,Shayne C. TI - In vitro toxicology SN - 9781560327691 (hbk.) : AV - RA1199.4.I5 U1 - 571.951028 GAD PY - 2000/// CY - Washington, D.C., London PB - Taylor & Francis KW - Toxicity testing KW - In vitro KW - Scientific equipment, experiments & techniques KW - thema KW - Medical toxicology KW - Neonatal medicine KW - Biochemistry KW - Science KW - ukslc KW - Toxicity Tests KW - methods KW - Cells, Cultured KW - drug effects KW - Drug Evaluation, Preclinical KW - Tissue Culture N1 - Previous ed.: 1994; Includes index; Introduction -- General principles for In vitro -- Ocular toxicity assessment In vitro toxicology -- In vitro methods to predict skin irritation -- Lethality testing -- In vitro genetic toxicity testing -- Pyrogenicity and muscle irritation -- In vitro models for evaluating developmental toxicity -- Neurotoxicology In vitro -- In vitro assessment of nephrotoxicity -- Primary hepatocyte culture as an In vitro toxicologic system for the liver -- Application of In vitro model systems to study cardiovascular toxicity -- Gastrointestinal toxicology: In vitro test systems -- In vitro immonotoxicology -- Strategy and tactics for employment -- Scientific and regulatory considerations in the development of In vitro techniques in toxicology -- Safety issues in the use of human tissue by In vitro metabolism and toxicology laboratories N2 - Increased concern over animal welfare has encouraged the development of in vitro models for use in identifying and understanding most forms of toxicity. This volume reviews both the uses and limitations of this now broad range of models ER -