The impact of stereochemistry on drug development and use / 
edited by Hassan Aboul-Enein. 
 - Chichester :  Wiley,  1997. 
 - 732p. 
 - Chemical analysis ;  v. 142 .
<br/><br/> Series no. on spine 134 [sic].  "A Wiley-Interscience publication." 
<br/><br/>Includes bibliographical references and index. 
<br/><br/>Chirality and drug hazards / Hassan Y. Aboul-Enein and Laila I. Abou Basha -- Stereochemistry in the drug development process : role of chirality as a determinant of drug action, metabolism, and toxicity / Thomas A. Baillie and Kathleen M. Schultz -- Stereochemical aspects of drug metabolism / Jonathan P. Mason and Andrew J. Hutt -- Some examples for stereoselective biotransformation of drugs / Gottfried Blaschke -- Kinetics of reactive phase II metabolites : stereochemical aspects of formation of epimeric acyl glucuronides and their reactivity / Hildegard Spahn-Langguth ... [et al.] -- Studies on the stereoselectivity of the biologically important metabolism of alkene-alkene oxide (oxirane)-alkanediol / Dorothee Wistuba -- Chiral barbiturates : synthesis, chromatographic resolutions, and biological activity / Jacek Bojarski -- Ethambutol and tuerculosis, a neglected and confused chiral puzzle / Bernard Blessington -- Stereogenic elements of pharmaceutical compounds : some aspects on isomerism, resolution, and stereochemical integrity / Stig G. Allen Mark -- The importance of chiral seperations in pharmaceuticals / Sut Ahuja -- Seperation of optically active pharmaceuticals using capillary electrophoresis / Timothy J. Ward and Karen D. Ward -- Chiral recognition mechanism of polysaccharides chiral stationary phases / Eji Yashima and Yoshio Okamoto -- Michelle-mediated capillary electrophoretic seperation of enantomeric compounds / Michael E. Swartz and Phyllis R. Brown -- Unified enantioselective chromatography involving chirasil-dex / Volker Schurig ... [et al.] -- Derivatized cyclodextrins as chiral gas chromatographic stationary phases and their potential applications in the pharmaceutical industry / Weiyong Li and Thomas M. Rossi -- Chiral derivatization reagents in the bioanalysis of optically active drugs with chromophore-based detection / Ralf Bu·schges ... [et al.] -- Circular dichroism spectroscopy in the analysis of chiral drugs / Piera Salvadori, Carlo Rosini, and Carlo Bertucci -- Circular Dichroism in the study of stereoselective binding of drugs to serum proteins / Carlo Bertucci, Piero Salvadori, and Enrico Domenici -- Current regulatory guidelines of stereoisomeric drugs : North American, European, and Japanese point of view / Sylvie Laganieþre -- Enantioselective analysis and the regulation of chiral drugs / Michael Gross -- First pass phenomena : sources of stereoselectives and variabilities of concentration-time profiles after oral dosage / Hildegard Spahn-Langguth ... [et al.] -- Gastrointestinal transport processes : potentials for stereoselectivities at substrate-specific and nonspecific epithelial transport systems / Peter Langguth -- Preparation of drug enantiomers by chromatographic resolution on chiral stationary phases / Eric Francotte 
<br/><br/> This volume discusses the impact of stereochemistry and chirality on drug development and use, including analytical, pharmacological and regulatory topics. 
<br/><br/><label>ISBN: </label>9780471596448 (hbk.) :  £55.60 0471596442 (acidfree paper) 
<br/><br/><label>LCCN: </label>96033491 
<br/><br/><label>Subjects--Topical Terms: </label><br/>Chiral drugs.<br/>Stereochemistry.<br/>Drugs--Design<br/>Pharmaceutical chemistry.<br/>Pharmaceutical chemistry & technology<br/>Analytical chemistry<br/>Pharmacology<br/>Medical research<br/>Health and Wellbeing.<br/>Chemistry, Pharmaceutical--methods<br/>Stereoisomerism.<br/>Molecular Conformation.
<br/><br/><label>Dewey Class. No.: </label>615.7 ABO