TY  - BOOK
AU  - Schiel,John E.
AU  - Davis,Darryl L.
AU  - Borisov,Oleg
AU  - Schiel,John E.
AU  - Davis,Darryl L.
AU  - Borisov,Oleg
ED  - American Chemical Society,
TI  - State-of-the-art and emerging technologies for therapeutic monoclonal antibody characterization
T2  - ACS symposium series
SN  - 9780841230293 (hbk.) :
AV  - QR186.85 .S73 2016
PY  - 2104///
CY  - Washington, DC
PB  - American Chemical Society
KW  - Immunoglobulins
KW  - Therapeutic use
KW  - Monoclonal antibodies
KW  - Pharmaceutical biotechnology
KW  - Biopharmaceutics
KW  - Health and Wellbeing
KW  - ukslc
KW  - Biochemistry
KW  - thema
KW  - Pharmacology
KW  - Organic chemistry
KW  - Pharmaceutical chemistry & technology
N1  - Includes bibliographical references and index; 1.Determination of the NIST mAB primary structure. Trina Formolo ... [et al] -- 2.Sequence varianst and sequence variant analysis in biotherapeutic protins. Oleg V. Borisov ... [et al] -- 3.Structural elucidation of post-translational modifications in monoclonal antibodies. Wenzhou Li ... [et al] -- 4.Orthogonal technologies for NIST mAB N-Glycan structure elucidation and quantitation. Justin M. Prien ... [et al] -- 5.Separation methods and orthogonal techniques. David A. Michels ... [et al] -- 6.Biophysical techniques for characterizing the higher order structure and interactions of monoclonal antibodies. Yatin Gokarn ... [et al] -- 7.Developability assessment of a proposed INST monoclonal antibody.Dorina Saro ... [et al] -- 8.Protein particles (0.01 æm, 0.01 æm. Dean C. Ripple and Linda O. Narhi -- 9.Analytical methods for the measurement of  host cell proteins and other process-related impurities. Kesh Prakahs and Weibin Chen
N2  - This volume looks at the characterisation of monoclonal antibodies (mAbs), focusing both on general aspects, techniques and regulatory concerns common to any recombinant protein as well as specific analytical results. It therefore serves as both a foundational body of NISTmAb product knowledge as well as an evaluation of its suitability as an industry-appropriate reference material
ER  -