Crystals, x-rays and proteins : comprehensive protein crystallography /
by Dennis Sherwood, Jon Cooper.
- Oxford : Oxford University Press, 2010.
- 656 p. : ill. ; 25 cm.
Update to: Crystals, X-rays, and proteins / Dennis Sherwood. 1976.
Includes bibliographical references and index.
Part I.Fundamentals -- 1.The crystalline state and its study -- 2.Vector analysis and complex algebra -- 3.Crystal systematics -- 4.Waves and electromagnetic radiation -- 5.Fourier transforms and convolutions -- 6.Diffraction -- Review I -- Part II.Diffraction theory -- 7.Diffraction by one-dimensional obstacles -- 8.Diffraction by a three-dimensional lattice -- 9.The contents of the unit cell -- Review II.Part III.Structure solution -- 10.Experimental techniques: sample preparation -- 11.Experimental techniques: data collection and analysis -- 12.The phase problems and the Patterson function -- 13.Molecular replacement -- 14.Solving the phase problem experimentally -- 15.Refinement -- 16.Complementary diffraction methods -- Review III.
Information derived from X-ray crystal structures of biological molecules allows us to explain their functions in living organisms and to develop drugs to treat disease. This book describes the principles and practice of X-ray diffraction as a key technique at the forefront of new discoveries in biology and medicine.