TY - BOOK AU - Pace,John L. AU - Rupp,Mark AU - Finch,R.G. TI - Biofilms, infection, and antimicrobial therapy SN - 9780824726430 (alk. paper) : AV - QR100.8.B55 B565 2006 U1 - 616.9041 PAC PY - 2006/// CY - Boca Raton, London PB - Taylor & Francis KW - Anti-infective agents KW - Pathogenic microorganisms KW - Biofilms KW - Pharmacology KW - thema KW - Infectious & contagious diseases KW - Molecular biology KW - Anti-Bacterial Agents KW - Infection KW - Prosthesis-Related Infections N1 - Includes bibliographical references and index; SECTION 1: Biofilms: Background, Significance, and Roles of Catheters and Indwelling Devices:- 1. Microbial Biofilms--2. Economic Impact of Biofilms on Treatment Costs--3. Biofilm-related indwelling medical device infections--4. Medical device composition and biological secretion influences on biofilm formation--SECTION II: Biofilm-Forming Pathogens:- 5. Role of biofillms in infections caused by Escherichia coli--6. Staphylococcus aureus biofilms--7. Coagulase-negative staphylococci--8. Pseudomonas aeruginosa biofilm infections in cystic fibrosis--9. Candida--SECTION III: Emerging Issues, Assays, and Models:- 10. Current perspectives on the Regulation of the ica Operon and biofilm formation in staphylococcus epidermidis--11. Cell-to-Cell communication in bacteria--12. Persisters: Specialized cells responsiblefor biofilm tolerance to antimicrobial agents--13. Minimal biofilm eradication concentration (MBEC) Assay: Susceptibility testing for biofilms--14. Environmental cues regulate virulence and biofilm formation--15. In Vivo Models for the study of biomaterial-associated infection by biofilm-forming staphylococci--16. Host response to Biofilms--SECTION IV: Overview of Antiinfective Agents and Clinical Therapy:-17. Pharmacodynamics and the treatment of IMD-Related infections--18. Protein synthesis inhibitors, fluoroquinolones, and rifampin for biofilm infections--19. B-Lactams for the treatment of biofilm-associated infections--20. Glycopeptide antibacterials and the treatment of biofilm-related infections--21. Antibiotic resistance in biofilms--22. Treatment protocols for Infections of vascular catheters--23. Treatment protocols for bacterial endocarditis and infection of electrophysiologic cardiac devices--24. Treatment protocol of infections of orthopedic devices N2 - Rather than existing in a planktonic or free-living form, evidence indicates that microbes show a preference for living in a sessile form within complex communities called biofilms. This book provides an exploration of biofilms, offering background information, and a look at the serious concerns to which biofilm-associated infections give rise ER -