TY - BOOK AU - Handen,Jeffrey S. TI - Industrialization of drug discovery: from target selection through lead optimization T2 - Drug discovery series SN - 9780824723910 (alk. paper) AV - RM301.25 .I53 2005 U1 - 615.19 HAN PY - 2005/// CY - Boca Raton, London PB - Taylor & Francis KW - Pharmaceutical industry KW - Drug development KW - Pharmacology KW - thema KW - Pharmaceutical chemistry & technology KW - Medical research KW - Drug Industry KW - organization & administration N1 - Includes bibliographical references and index; Chapter 1.Drug discovery in the modern age: how we got here and what does it mean? -- Chapter 2.The regulatory age -- Chapter 3.Industrialization, not automation -- Chapter 4.Compound management -- Chapter 5.High through-put screening -- Chapter 6.Parallel lead optimization -- Chapter 7.Knowledge management -- Chapter 8.Understanding the value of research -- Chapter 9.Collaboration in a virtual and global environment -- Chapter 10.From genome to drug: ethical issues N2 - In light of statistics and experience showing that drug discovery and development is getting longer, more expensive, and no better in the sense that the clinical attrition and safety-related market withdrawals today are about the same as they were 20 years ago contributors from pharmaceutical companies and some universities explore a new approach t ER -