Integrated pharmacology / Clive Page ... [et al.].

Previous ed.: 1997.

Illustrators, Mick Ruddy, Marion Tasker.

Text and ill. on inside cover.

Includes bibliographical references and index.

deficiency anemia--Deferoxamine and iron overload--Vitamin B12, folate, and other macrocytic anemias--Hematopoietic growth factors--Hemostatic disorders and antithombotic therapy--Hemostasis--Thrombosis--Bleeding disorders--14. Drugs:- Physiology of the central and peripheral nervous system--Functional anatomy of the peripheral nervous system--Pathophysiology and diseases of the peripheral nervous system--Skeletal muscle disorders--Anticholinesterase drugs--Spasticity--Movement disorders resulting from defects in muscle excitability--Functional neurochemistry of the nervous system--Pathophysiology and diseases of the central nervous system--Psychosis--Schizophrenia--Afffective disorders--Antidepressants--Mood stabilizers-- Eating disorders--Epilepsy--Sleep disorders-- Hypnotics--Sleep apnea--Periodic limb movement disorder--Dementia--Parkinson\'s disease--Huntington\'s disease--Migraine and headache--stroke--Drugs and infections of the central nervous system--Pain --Testing analgesic drugs--Drug therapy of pain--Drugs of abuse-- 15. Drugs and the Endocrine and Matabolic Systems:- General physiology of the endocrine and metabolic systems-- Pathophysiology and diseases of the endocrine and metabolic systems--Pharmacologic principles--Diseases of the pituitary --Thyroid diseases and disorders of metabolic rate--Disorders of carbohydrate metabolism--Disorders of lipid metabolism--Disorders of glucocorticosteroids and the stress response hormones--Drugs and the endocrinology of the reproductive system--Physiology of the female reproductive tract-- Diseases treated by estrogens and estrogen antagonists-- Contraception and menstruation--Hormone replacement therapy--Disorders of sex steroids in premenopausal women--Androgen excess in women--Androgen excess and deficiency in men--16. Drugs and the inflammatory and immune responses:- Physiology of the immune system and inflammatory response-- Pathophysiology and diseases of the immune system-- Hypersensitivity reactions and immunologic diseases -- Drug therapy for allergic diseases --Mechanisms of actions of drugs used for autoimmune diseases-- 17. Drugs and the Renal System:- Physiology of the kidneys --Pathophysiology and diseases of the renal system-- Edema --Diuretics--Polyuria -- Syndrome of inappropriate vasopressin secretion-- Renal stones ( nephrolithiasis) -- Oliguria--Chronic renal failure-- Drugs contraindicated in renal failure--Glomerulonephritis--Dialysis and drug therapy--Nephrotoxic drugs--18. Drugs and the Cardiovascular system --19. Drugs and the Pulmonary System--20. Drugs and the Musculoskeletal system--21. Drugs and the Gastrointestinal system--22. Drugs and the Genitourinary System-- 23. Drugs and the skin--24. Drugs and the eye--25. Drugs and the Ear-- 26. Drug use in Anesthesia and critical care-- 27. Drug use in Disorders of nutrition-- 28. Drug use in Dentistry--29. Toxins and Poisons--30. Herbs.

Section 1.Principles of pharmacology -- 1.Introduction--What is pharacology?--History of Pharmacology -- 2.Drug names and drug classification systems--Introduction--What is a drug?--Drug names--Drug classification systems-- 3.General principles of drug acton--What does a drug do and how does it do it?--Molecular actions of drugs--Cellular actions of drugs (transduction)--Tissue and system actions of drugs--The future of pharmacology -- 4.Pharmacokinetic and other factors influencing drug action--Drug delivery--Factors influencing drug absorption and distribution--Drug metabolism--Drug excretion--Pharmacokinetics--Age, sex, and origin--Drug interactions--Effect of disease on drug action -- 5. Pharmacodynamics and the measurement of drug action--The receptor--Dose-response curves--Measuring responses and practical applications of dose-response curves-- 6. Drug saftey and pharmacovigilance--Pharmacotherapeutic decision-making --Controlling drug safety--Detecting adverse drug reactions -- 7. Regulation of drug use--Stages in drug development--Drug regulation for new drugs--Drug regulations relating to acces to drugs-- Section 2: Drug action on pathogens and neoplastic cells -- 8. Drugs and viruses--Biology and drug responsiveness of viruses--Classification of antiviral drugs and their sites of action in viral replication--Inhibitors of uncoating--Inhibitors of transcription--Inhibition of translation--Inhibition of RNA or DNA genomic replication--Inhibitors of virus release--Inhibitors of HIV replication--Nucleoside reverse transcriptase inhibitors--Non-nucleoside reverse transcriptase inhibitors--Cytochrome P-450 interactions -- 9. Drugs and bacteria--Mechanism of action--Selecting antibiotic therapy--Major antibiotics--Antibiotics that inhibit bacterial wallsynthesis--Antibiotics that inhibit bacterial cell membrane functioning--Antibiotics that inhibit bacterial protein synthesis--Antibiotics that inhibit bacterial deoxyribonucleic acid synthesis--Antibiotics that inhibit bacterial ribonucleic acid synthesis--Antifolates--Miscellaneous antibacterial drugs--Antimycobacterial drugs--Antibiotics of choice -- 10. Drugs and fungi--Biology of fungi--Management of fungal infections--General measures for infected patients--Specific antifungal treatment--Neutropenia and suspected fungal infection--Nonspecific treatment of fungal infections-- 11. Drugs and parasites--Protozoan diseases--Malaria--Antimalarial drugs--African trypanosomiasis (sleeping sickness--American trypanosomiasis (chagas disease)--Leishmaniasis--Other protozoan diseases--Helminthic diseases--Nematode (roundworm) infections--Trematode infections--Cestode infections -- 12.Drugs and neoplasms--Tumorigenesis--Principles of cell proliferation and chemotherapy--Principles of combination chemotherapy--Late complications of cancer chemotherapy--Gonadal dysfunction--Carcinogenesis--Resistance to chemotherapy--Antineoplastic drugs--Drugs directly interfering with DNA--Alkylating Agents--Nitrosoureas--Miscellaneous alkylating agents--Platinum compounds--Agents indirectly damaging DNA--Anthracyclines---- Section 3: Drug action on body system targets:- 13.Drugs and the blood:- Physiology of the hemopoietic system-- Drugs used for diseases of the blood--Anemia and agents used to treat anemia-- Iron and iron-

This volume takes a unique approach to pharmacology, considering drugs in the context of the diseases they are used to treat all within a body systems' framework.