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Medicinal chemistry : principles and practice / edited by Frank D. King.

Contributor(s): Material type: TextTextPublication details: Cambridge : Royal Society of Chemistry, c1994.Description: xxi,313pISBN:
  • 9780851864945 (pbk) :
  • 9780851864945
Subject(s): DDC classification:
  • 615.19 KIN
Contents:
An introduction to drug-receptor interactions / Barry Hunt -- Signal transduction and second messengers / Trevor J. Franklin -- Enzyme inhibitors / David A. Roberts -- The biological evaluation of new compounds / Robert A. Coleman -- Pharmacokinetics / Robert M.J. Ings -- Drug metabolism / Colin Vose -- Physicochemical properties and drug design / Nigel P. Gensmantel -- Quantitative structure-activity relationships / Andrew M. Davis -- Considerations for the use of computational chemistry techniques by medicinal chemists / Mike M. Hann -- 'Patent medicine' / Bill Tyrrell -- Molecular biology : a new route to drug discovery / Janet E. Carey -- Devising a research strategy / Colin W. Greengrass -- Past approaches to discovering new drugs as medicines / C. Robin Ganellin -- Bioisosteres, conformational restriction and pro-drugs : approaches to lead optimisation, case history : an example of a conformational restriction approach / Frank D. King -- The design and synthesis of selective protein kinase C inhibitors / Christopher H. Hill -- Discovery of 1069C : a novel synthetic antitumour agent with low cross-resistance potential / Simon T. Hodgson -- The design and biological properties of 'dipeptoid' antagonists / David C. Horwell -- Migraine therapy : from serotonin to sumatriptan / Peter C. North -- Drug development / Jane Ormerod.
Summary: An introduction to the subject, aimed primarily at synthetic chemists, which explains how to identify a drug candidate from an initial lead compound that possesses the properties required for successful development. The main aim of the text is to address the quality of interpretations.
Holdings
Item type Current library Call number Copy number Status Date due Barcode
Short Loan TUS: Midlands, Main Library Athlone General Lending 615.19 KIN (Browse shelf(Opens below)) 1 Available 104918

"Lectures presented at the 7th RSC Medicinal Chemistry School held between 28th June and 3rd July in 1993 at the University of Kent, Canterbury, UK"--Pref.

Includes bibliographical references and subject index.

An introduction to drug-receptor interactions / Barry Hunt -- Signal transduction and second messengers / Trevor J. Franklin -- Enzyme inhibitors / David A. Roberts -- The biological evaluation of new compounds / Robert A. Coleman -- Pharmacokinetics / Robert M.J. Ings -- Drug metabolism / Colin Vose -- Physicochemical properties and drug design / Nigel P. Gensmantel -- Quantitative structure-activity relationships / Andrew M. Davis -- Considerations for the use of computational chemistry techniques by medicinal chemists / Mike M. Hann -- 'Patent medicine' / Bill Tyrrell -- Molecular biology : a new route to drug discovery / Janet E. Carey -- Devising a research strategy / Colin W. Greengrass -- Past approaches to discovering new drugs as medicines / C. Robin Ganellin -- Bioisosteres, conformational restriction and pro-drugs : approaches to lead optimisation, case history : an example of a conformational restriction approach / Frank D. King -- The design and synthesis of selective protein kinase C inhibitors / Christopher H. Hill -- Discovery of 1069C : a novel synthetic antitumour agent with low cross-resistance potential / Simon T. Hodgson -- The design and biological properties of 'dipeptoid' antagonists / David C. Horwell -- Migraine therapy : from serotonin to sumatriptan / Peter C. North -- Drug development / Jane Ormerod.

An introduction to the subject, aimed primarily at synthetic chemists, which explains how to identify a drug candidate from an initial lead compound that possesses the properties required for successful development. The main aim of the text is to address the quality of interpretations.

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