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Peroxisomes : biology and importance in toxicology and medicine / edited by Gordon Gibson and Brian Lake.

Contributor(s): Material type: TextTextPublication details: London : Taylor & Francis, 1993.Description: xiv,734pISBN:
  • 9780748400539 :
  • 0748400532 (alk. paper) :
Subject(s): DDC classification:
  • 574.874 GIB
Contents:
(cont) Hepatic changes associated with peroxisome proliferation -- Peroxisome proliferators as initiators and promoters of rodent hepatocarcinogensis -- Are peroxisome proliferators tumour promoters in rat liver? -- Risk assessment of chemicals inducing peroxisome proliferation.
Peroxisome biogenesis -- Metabolic role of mammalian peroxisomes -- Peroxisomal disorders -- Molecular mechanism of peroxisome proliferator action -- Peroxisome proliferators as cytochrome P450 inducers -- Peroxisome proliferation: lipid metabolism and receptors -- Molecular mechanisms involved in induction of peroxisomal -oxidation enzymes by hypolipidaemic agents -- Molecular basis of gene regulation by peroxisome proliferators -- Molecular evolution of the urate oxidase encoding gene and its functional significance -- Possible role of CoASH esters on xenobiotic-induced peroxisomal proliferation and non-genotoxic carcinogenesis -- Modulation of peroxisomal biogenesis and lipid metabolising enzymes by dietary factors.
(cont) Proliferation of peroxisomes and mitochondria and modulation of lipid metabolizing enzymes by hypolipidaemic, non--oxidizable fatty acids (3-thia fatty acids) -- Cultured hepatocytes: a useful in vitro system to investigate effects induced by peroxisome proliferators and their species specificity -- Structure-activity relationships for chemically induced peroxisome proliferation in mammalian liver -- Tetrazole substituted acetophenone peroxisome proliferators: structure-activity relationships and effects on hepatic lipid metabolism -- Structural requirements for peroxisome proliferation by phenoxyacetic and fatty acid analogues in primary cultures of rat hepatocytes -- Ultrastructural and biochemical aspects of peroxisome proliferation and biogenesis in different mammalian species -- Toxicological studies in primates with three fibrates.
Structure-, enantiomer- and species-specific effects of fibrate analogues on peroxisome proliferation and increased activity of mitochondrial -glycerophosphate dehydrogenase -- Metabolism of di-(2-ethylhexyl)phthalate (DEHP) and di-(2-ethylhexyl)adipate (DEHA) and their relationship to peroxisome proliferation in different species -- Extrahepatic peroxisome proliferation and the extrahepatic effects of peroxisome proliferators -- Biological aspects of peroxisome proliferator-induced liver tumours in the rat -- Genotoxicity studies of peroxisome proliferators -- Production of 8-hydroxydeoxyguanosine in rodent liver by the administration of peroxisome proliferators -- Role of oxidative stress and enhanced cell replication in the hepatocarcinogenicity of peroxisome proliferators -- Hyperplastic responses to peroxisome proliferators.
Summary: Provides an update on several new aspects of peroxisome biology, including the role of the peroxisome proliferator activated receptor. The book covers morphilogical, biochemical and molecular biological aspects of peroxisomes.
Holdings
Item type Current library Call number Copy number Status Date due Barcode
Long Loan TUS: Midlands, Main Library Athlone General Lending 574.874 GIB (Browse shelf(Opens below)) 1 Available 110628

Includes bibliographical references and index.

(cont) Hepatic changes associated with peroxisome proliferation -- Peroxisome proliferators as initiators and promoters of rodent hepatocarcinogensis -- Are peroxisome proliferators tumour promoters in rat liver? -- Risk assessment of chemicals inducing peroxisome proliferation.

Peroxisome biogenesis -- Metabolic role of mammalian peroxisomes -- Peroxisomal disorders -- Molecular mechanism of peroxisome proliferator action -- Peroxisome proliferators as cytochrome P450 inducers -- Peroxisome proliferation: lipid metabolism and receptors -- Molecular mechanisms involved in induction of peroxisomal -oxidation enzymes by hypolipidaemic agents -- Molecular basis of gene regulation by peroxisome proliferators -- Molecular evolution of the urate oxidase encoding gene and its functional significance -- Possible role of CoASH esters on xenobiotic-induced peroxisomal proliferation and non-genotoxic carcinogenesis -- Modulation of peroxisomal biogenesis and lipid metabolising enzymes by dietary factors.

(cont) Proliferation of peroxisomes and mitochondria and modulation of lipid metabolizing enzymes by hypolipidaemic, non--oxidizable fatty acids (3-thia fatty acids) -- Cultured hepatocytes: a useful in vitro system to investigate effects induced by peroxisome proliferators and their species specificity -- Structure-activity relationships for chemically induced peroxisome proliferation in mammalian liver -- Tetrazole substituted acetophenone peroxisome proliferators: structure-activity relationships and effects on hepatic lipid metabolism -- Structural requirements for peroxisome proliferation by phenoxyacetic and fatty acid analogues in primary cultures of rat hepatocytes -- Ultrastructural and biochemical aspects of peroxisome proliferation and biogenesis in different mammalian species -- Toxicological studies in primates with three fibrates.

Structure-, enantiomer- and species-specific effects of fibrate analogues on peroxisome proliferation and increased activity of mitochondrial -glycerophosphate dehydrogenase -- Metabolism of di-(2-ethylhexyl)phthalate (DEHP) and di-(2-ethylhexyl)adipate (DEHA) and their relationship to peroxisome proliferation in different species -- Extrahepatic peroxisome proliferation and the extrahepatic effects of peroxisome proliferators -- Biological aspects of peroxisome proliferator-induced liver tumours in the rat -- Genotoxicity studies of peroxisome proliferators -- Production of 8-hydroxydeoxyguanosine in rodent liver by the administration of peroxisome proliferators -- Role of oxidative stress and enhanced cell replication in the hepatocarcinogenicity of peroxisome proliferators -- Hyperplastic responses to peroxisome proliferators.

Provides an update on several new aspects of peroxisome biology, including the role of the peroxisome proliferator activated receptor. The book covers morphilogical, biochemical and molecular biological aspects of peroxisomes.

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