Molecular and biochemical toxicology. edited by, Dr. Robert C. Smart, North Carolina State University, Raleigh, NC, USA, Dr. Ernest Hodgson, North Carolina State University, Raleigh, NC, USA.
Material type:
TextPublisher: Hoboken, NJ : Wiley [2018]Edition: Fifth edition. / edited by Robert C. Smart, Ernest HodgsonDescription: 1016 pagesISBN: - 9781119042419 (hbk.) :
- 9781119042419 (hardback)
- 615.9 SMA 23
- RA1219.5 .I58 2018
| Item type | Current library | Call number | Status | Date due | Barcode | |
|---|---|---|---|---|---|---|
| Long Loan | TUS: Midlands, Main Library Athlone General Lending | 615.9 SMA (Browse shelf(Opens below)) | Available | 224119 |
Previous edition: 2008.
Includes bibliographical references and index.
Section 1.Introduction 1.Molecular and biochemical toxicology: definition and scope. Ernest Hodgson and Robert C. Smart Section 2.Techniques in biochemical and molecular toxicology 2.Molecular techniques for the study of gene function. Yoshiaki Tsuji and Robert C. Smart 3.Transcriptomics. B. Alex Merrick 4.Proteomics. Michael S. Bereman 5.Metabolomics. Susan C. J. Sumner, Wimal Pathmasiri, James E.Carlson, Susan L. McRitchie and Timothy R. Fennell 6.Cellular techniques. Sharon A. Meyer and Barbara A. Wetmore 7.Basic concepts of molecular epidemiological research methods. Cathrine Hoyo, David A. Skaar, and Randy J. Jirtle Section 3.Mechanisms in molecular and biochemical toxicology Phase I and Phase II. Metabolism and metabolic interactions: a summary. Ernest Hodgson 9.Structure, mechanism, and regulation of cytochromes P450. John M. Seubert, Matthew L. Edin, and Darryl C. Zeldin 10.Polymorphisms in Phase and Phase II genes and outcomes. Yoshiaki Tsuji, Edward L. Croom, and Ernest Hodgson 11.Cellular transport and elimination. David S. Miller and Ronald E. Cannon 12.Nuclear receptors. Seth W. Kullman, William S. Baldwin, and Gerald A. LeBlanc 13.Mechanisms of cell death. Mac Law and Susan Elmore 14.Mitochondrial dysfunction. Jun Ninomiya-Tsuji 15.Reactive metabolites, reactive oxygen species (ROS).ELizabeth L. MacKensie and Yoshiaki Tsuji 16.DNA damage and mutagenesis. Zhiang Wang 17.DNA repair. Isabel Mellon 18.Carcinogenesis. Robert C,. Smart and Jonathan R. Hall 19.Molecular mechanisms of respiratory toxicity. James C. Bonner 20.Molecular mechanisms of hepatotoxicity. Supriya R. Kulkarni, Andrew D. Wallace, Sharon A. Meyer, and Angela L. Slitt 21.Molecular mechanisms of renal toxicology. Lawrence H. Lash 22.Molecular mechanisms of neurotoxicity. Kimberly P. Keil. Marianna Stamou, and Pamela J. Lein 23.Molecular mechanisms of immunotoxicity. Tai L. Gou, Joella Xu, Yingjia Chen, Daniel E. Lefever, Guannan Huang, and David A. Lawrence 24.Molecular mechanisms of reproductive toxicity. Ayelet Ziv-Gal, Catheryne Chiang, and Jodi Anne Flaws 25.Molecular mechanisms of developmental toxicity. Antonio Planchart Section 5.Emerging areas in molecular and biochemical toxicology 26.Computational and molecular approaches to risk assessment. Richard S. Judson, John Wambaugh, Kristin Isaacs, and Russell S. Thomas 27.Nanotoxicology. James C. Bonner 28.Developmental origins of health and disease. Michael Cowley 29.Exposome. Stephen M. Rappaport
This introductory book provides in-depth information on the underlying biochemical, molecular, and cellular mechanisms through which toxicants produce their adverse responses. Toxicologic issues are covered from both an organ-based approach along with the basic principles of toxicology and methodology.